The antibody-drug conjugates market is fast evolving and is expected to grow significantly during the forecast period. The effectiveness of ADCs and checkpoint inhibitors in combating cancer is having a massive impact on the ADC R&D market; additionally, new and exciting uses of antibody-drug conjugates are also being actively researched.
New York, USA, Feb. 20, 2025 (GLOBE NEWSWIRE) — Antibody-Drug Conjugates Market to Witness Rapid Growth Across 7MM During the Study Period (2020–2034) as New Innovations Drive Therapy Advancements | DelveInsight
The antibody-drug conjugates market is fast evolving and is expected to grow significantly during the forecast period. The effectiveness of ADCs and checkpoint inhibitors in combating cancer is having a massive impact on the ADC R&D market; additionally, new and exciting uses of antibody-drug conjugates are also being actively researched.
DelveInsight’s
Key Emerging Antibody-drug Conjugates and Companies
Some of the emerging drugs are telisotuzumab vedotin, patritumab deruxtecan, ladiratuzumab vedotin, and camidanlumab tesirine, among others. Key players, such as ImmunoGen, Daiichi Sankyo, Seagen, Merck, ADC Therapeutics, CytomX, AbbVie, and others are involved in developing ADCs for indications such as non-small lung cancer, breast cancer, gynecological cancer, hematologic malignancies, and solid tumors.
Telisotuzumab vedotin is an ADC targeting cMet, currently under investigation for the treatment of NSCLC. The drug is being tested in the Phase III clinical trial TeliMET NSCLC-01 (M18-868) by AbbVie. In January 2022, AbbVie announced that the US FDA had granted Breakthrough Therapy Designation (BTD) for telisotuzumab vedotin to treat patients with advanced or metastatic EGFR wild-type, non-squamous NSCLC who have high levels of c-Met overexpression and whose disease has progressed after platinum-based therapy.
In September 2024, the company announced the submission of a Biologics License Application (BLA) to the US FDA for accelerated approval of telisotuzumab vedotin in adult patients with previously treated, locally advanced or metastatic EGFR wild-type, non-squamous NSCLC with c-Met protein overexpression.
Patritumab deruxtecan is an investigational ADC targeting HER3. Developed using Daiichi Sankyo’s proprietary DXd ADC technology, it combines a fully human anti-HER3 IgG1 monoclonal antibody with topoisomerase I inhibitor payloads (an exatecan derivative, DXd) connected by cleavable tetrapeptide-based linkers. The drug received Breakthrough Therapy Designation (BTD) from the US FDA in December 2021 for treating patients with EGFR-mutated locally advanced or mNSCLC.
It is currently being tested in multiple Phase I, II, and III clinical trials. In October 2023, Daiichi Sankyo and Merck established a global partnership to develop and commercialize three DXd ADC candidates, including patritumab deruxtecan, ifinatamab deruxtecan (I-DXd), and raludotatug deruxtecan (R-DXd). In June 2024, the FDA issued a complete response letter regarding the approval application for third-line treatment of EGFR-mutated NSCLC based on Phase II trial results. In September 2024, the Phase III trial for second-line treatment of EGFR-mutated NSCLC (HERTHENA-Lung02) met its primary endpoint.
Seagen is a frontrunner in ADC research and its application in cancer treatment. Their antibody-drug conjugate product candidates include Ladiratuzumab vedotin, an ADC targeting LIV-1, which is currently undergoing Phase I/II clinical trials in combination with pembrolizumab for the first-line treatment of patients with unresectable locally advanced or metastatic triple-negative breast cancer.
The other ADCs in the pipeline include
- Dato-DXd: AstraZeneca/Daiichi Sankyo
- BNT323/DB-1303: BioNTech/Duality Biologics
- A166: Klus Pharma
- JNJ-0683 (ARX788): Ambrx/Johnson & Johnson Innovative Medicine
- GQ1001: GeneQuantum Healthcare (Suzhou)
- CUSP06: OnCusp Therapeutics, and others
The anticipated launch of these emerging ADCs are poised to transform the ADC market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the ADC market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
To know more about ADCs clinical trials, visit @ Antibody-drug Conjugates in Development
Antibody-drug Conjugates Overview
Antibody-drug conjugates (ADCs) are a class of targeted cancer therapies that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. The monoclonal antibody component of the ADC is engineered to recognize and bind to specific antigens found on the surface of cancer cells. Once bound, the ADC is internalized into the cancer cell, where the cytotoxic drug is released, delivering a highly targeted dose of chemotherapy directly to the tumor. This approach helps to minimize the systemic toxicity commonly associated with traditional chemotherapy, as the drug is delivered specifically to cancer cells rather than affecting healthy tissues.
The development of ADCs has led to significant advancements in cancer treatment, particularly for tumors that are resistant to conventional therapies. ADCs are designed to overcome some of the challenges in cancer therapy, such as off-target toxicity and drug resistance, by ensuring that the cytotoxic payload is only active inside cancer cells. However, the design and optimization of ADCs remain complex, involving careful selection of the monoclonal antibody, the cytotoxic drug, and the linker that connects them. Ongoing research is focused on improving the stability, potency, and selectivity of ADCs to enhance their therapeutic efficacy while minimizing side effects.
Antibody-drug Conjugates Epidemiology Segmentation
As per DelveInsight analysis, the total incident cases of TNBC in the United States comprised nearly 45K cases in 2023. The total number of incident cases of NSCLC in the 7MM were ~531K cases in 2023 which is expected to grow during the forecast period 2024–2034. Estimates show that the highest incident population of NSCLC is in the United States followed by Japan. The antibody-drug conjugates market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM segmented into:
- Total Cases of Selected Indications for ADC
- Total Eligible Patient Pool for ADCs in Selected Indications
- Total Treated Cases in Selected Indications
Download the report to understand what epidemiologists are saying about ADCs patient trends in 7MM @ Antibody-drug Conjugates Patient Pool
| Antibody-drug Conjugates Report Metrics | Details |
| Study Period | 2020–2034 |
| Antibody-drug Conjugates Report Coverage | 7MM [the United States, the EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan] |
| Key ADCs Companies | AbbVie, Daiichi Sankyo, Merck, Pfizer, Seagen, AstraZeneca, BioNTech, Duality Biologics, Klus Pharma, Ambrx, Johnson & Johnson Innovative Medicine, GeneQuantum Healthcare (Suzhou), OnCusp Therapeutics, and others |
| Key ADC in the Pipeline | Telisotuzumab vedotin (ABBV-399), Patritumab deruxtecan (HER3-DXd), Ladiratuzumab vedotin, Dato-DXd, BNT323/DB-1303, A166, JNJ-0683 (ARX788), GQ1001, CUSP06, and others |
Scope of the Antibody-drug Conjugates Market Report
- Antibody-drug Conjugates Therapeutic Assessment: Antibody-drug Conjugates current marketed and emerging therapies
- Antibody-drug Conjugates Market Dynamics: Conjoint Analysis of Emerging Antibody-drug Conjugates Drugs
- Competitive Intelligence Analysis: SWOT analysis and Market entry strategies
- Unmet Needs, KOL’s views, Analyst’s views, Antibody-drug Conjugates Market Access and Reimbursement
Discover more about ADC drugs in development @ Antibody-drug Conjugates Clinical Trials
Table of Contents
| 1. | Antibody-drug Conjugates Market Key Insights |
| 2. | Antibody-drug Conjugates Market Report Introduction |
| 3. | Executive Summary of Antibody-drug Conjugates |
| 4. | Key Events |
| 5. | Antibody-drug Conjugates Market Forecast Methodology |
| 6. | Antibody-drug Conjugates Market Overview at a Glance in the 7MM |
| 7. | Antibody-drug Conjugates: Background and Overview |
| 8. | Antibody-drug Conjugates Target Patient Pool |
| 9. | Antibody-drug Conjugates Marketed Drugs |
| 10. | Antibody-drug Conjugates Emerging Drugs |
| 11. | Seven Major Antibody-drug Conjugates Market Analysis |
| 12. | Antibody-drug Conjugates Market Access and Reimbursement |
| 13. | SWOT Analysis |
| 14. | KOL Views |
| 15. | Unmet Needs |
| 16. | Appendix |
| 17. | DelveInsight Capabilities |
| 18. | Disclaimer |
| 19. | About DelveInsight |
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